| Rank | Movie Title (click to view) | Studio | Total Gross / Theaters | Opening / Theaters | Open | Close | ||
| A Good Woman | Lions | $238,609 | 35 | $97,060 | 35 | 2-Mar | Feb-23 | |
| Battle in Heaven | Tar. | $70,353 | 5 | $20,351 | 2 | 1-Feb | - | |
| Night Watch (Nochnoi Dozor) | FoxS | $1,502,188 | 158 | 86985 | 3 | 1-Feb | 42156 | |
| running with scissors | $6,754,898 | |||||||
| Hoot | NL | $8,117,637 | 3018 | 3368197 | 3018 | 5-May | 38935 | |
| Tenacious D in: The Pick of Destiny | NL | $8,081,469 | 1919 | 3234879 | 1919 | 1-Nov | - | |
| The Night Listener | Mira. | $7,836,393 | 1370 | 3554134 | 1367 | 8-Apr | 38907 | |
| Slither | Uni. | $7,802,450 | 1946 | 3880270 | 1945 | 1-Mar | 46478 | |
| The Return | Rog. | $7,744,785 | 1986 | 4479621 | 1986 | 11-Oct | - | |
| Doogal | Wein. | $7,417,319 | 2319 | 3605899 | 2318 | 1-Feb | 41365 | |
| All the King's Men | Sony | $7,221,458 | 1520 | 3672366 | 1514 | 1-Sep | 42278 | |
| American Dreamz | Uni. | $7,191,830 | 1500 | 3667420 | 1500 | 1-Apr | 43221 | |
| A Good Year | Fox | $7,368,152 | 2067 | 3721526 | 2066 | 11-Oct | - | |
| Something New | Focus | $11,468,568 | 1265 | 4879736 | 1265 | 2-Mar | 39328 | |
| Little Children | 5,459,824 | |||||||
| harsh times | $3,337,931 | |||||||
| For your Consideration | $5,549,923 | |||||||
| Home of the Brave | $6,000 | |||||||
| Miss Potter | 2,072,956 | |||||||
| Bobby | $11,205,901 | |||||||
| 1 | Pirates of the Caribbean: Dead Man's Chest | BV | $423,315,812 | 4,133 | $135,634,554 | 4,133 | 7-Jul | 12-Jul |
| 2 | Night at the Museum | Fox | $248,532,584 | 3,768 | $30,433,781 | 3,685 | Dec-22 | - |
| 3 | Cars | BV | $244,082,982 | 3,988 | $60,119,509 | 3,985 | 6-Sep | Oct-19 |
| 4 | X-Men: The Last Stand | Fox | $234,362,462 | 3,714 | $102,750,665 | 3,690 | May-26 | Sep-28 |
| 5 | The Da Vinci Code | Sony | $217,536,138 | 3,757 | $77,073,388 | 3,735 | May-19 | Aug-20 |
| 6 | Superman Returns | WB | $200,081,192 | 4,065 | $52,535,096 | 4,065 | Jun-28 | 11-Feb |
| 7 | Happy Feet | WB | $197,756,995 | 3,804 | $41,533,432 | 3,804 | Nov-17 | - |
| 8 | Ice Age: The Meltdown | Fox | $195,330,621 | 3,969 | $68,033,544 | 3,964 | Mar-31 | 9-Jul |
| 9 | Casino Royale | Sony | $167,445,960 | 3,443 | $40,833,156 | 3,434 | Nov-17 | - |
| 10 | The Pursuit of Happyness | Sony | $163,566,459 | 3,169 | $26,541,709 | 2,852 | Dec-15 | - |
| 11 | Over the Hedge | P/DW | $155,019,340 | 4,093 | $38,457,003 | 4,059 | May-19 | 9-Apr |
| 12 | Talladega Nights: The Ballad of Ricky Bobby | Sony | $148,213,377 | 3,807 | $47,042,215 | 3,803 | 8-Apr | Oct-15 |
| 13 | Click | SonR | $137,355,633 | 3,764 | $40,011,365 | 3,749 | Jun-23 | Sep-24 |
| 14 | Mission: Impossible III | Par. | $134,029,801 | 4,059 | $47,743,273 | 4,054 | 5-May | Jul-20 |
| 15 | The Departed | WB | $132,384,315 | 3,017 | $26,887,467 | 3,017 | 10-Jun | - |
| 16 | Borat: Cultural Learnings of America for Make Benefit Glorious Nation of Kazakhstan | Fox | $128,505,958 | 2,611 | $26,455,463 | 837 | 11-Mar | Mar-25 |
| 17 | The Devil Wears Prada | Fox | $124,740,460 | 2,882 | $27,537,244 | 2,847 | Jun-30 | Dec-14 |
| 18 | The Break-Up | Uni. | $118,703,275 | 3,146 | $39,172,785 | 3,070 | 6-Feb | 9-Jul |
| 19 | Dreamgirls | P/DW | $103,192,980 | 2,797 | $378,950 | 3 | Dec-15 | - |
| 20 | Scary Movie 4 | W/Dim. | $90,710,620 | 3,674 | $40,222,875 | 3,602 | Apr-14 | 8-Mar |
| 21 | Failure to Launch | Par. | $88,715,192 | 3,202 | $24,411,322 | 3,057 | 3-Oct | Jun-22 |
| 22 | Inside Man | Uni. | $88,513,495 | 2,867 | $28,954,945 | 2,818 | Mar-24 | 7-Jun |
| 23 | The Santa Clause 3: The Escape Clause | BV | $84,500,122 | 3,458 | $19,504,038 | 3,458 | 11-Mar | - |
| 24 | Open Season | Sony | $84,303,558 | 3,833 | $23,624,548 | 3,833 | Sep-29 | 12-Mar |
| 25 | Charlotte's Web (2006) | Par. | $82,599,768 | 3,745 | $11,457,353 | 3,566 | Dec-15 | - |
| 26 | The Pink Panther | Sony | $82,226,474 | 3,477 | $20,220,412 | 3,477 | 2-Oct | Apr-16 |
| 27 | Eight Below | BV | $81,612,565 | 3,122 | $20,188,176 | 3,066 | Feb-17 | 6-Jan |
| 28 | Saw III | LGF | $80,238,724 | 3,167 | $33,610,391 | 3,167 | Oct-27 | Dec-14 |
| 29 | Nacho Libre | Par. | $80,197,993 | 3,083 | $28,309,599 | 3,070 | Jun-16 | 9-Apr |
| 30 | You, Me and Dupree | Uni. | $75,628,110 | 3,137 | $21,525,560 | 3,131 | Jul-14 | 10-May |
| 31 | Eragon | Fox | $75,030,163 | 3,030 | $23,239,907 | 3,020 | Dec-15 | - |
| 32 | Monster House | Sony | $73,661,010 | 3,553 | $22,217,226 | 3,553 | Jul-21 | Oct-22 |
| 33 | Jackass: Number Two | Par. | $72,778,712 | 3,063 | $29,002,002 | 3,059 | Sep-22 | Nov-30 |
| 34 | Barnyard: The Original Party Animals | Par. | $72,637,803 | 3,311 | $15,820,864 | 3,311 | 8-Apr | 11-Feb |
| 35 | RV | Sony | $71,726,025 | 3,651 | $16,414,767 | 3,639 | Apr-28 | Aug-20 |
| 36 | V for Vendetta | WB | $70,511,035 | 3,365 | $25,642,340 | 3,365 | Mar-17 | Jun-29 |
| 37 | World Trade Center | Par. | $70,278,893 | 3,021 | $18,730,762 | 2,957 | 8-Sep | Oct-19 |
| 38 | Rocky Balboa | MGM | $70,269,899 | 3,019 | $12,158,168 | 3,017 | Dec-20 | Mar-29 |
| 39 | Big Momma's House 2 | Fox | $70,165,972 | 3,261 | $27,736,056 | 3,261 | Jan-27 | 6-Jan |
| 40 | Step Up | BV | $65,328,121 | 2,647 | $20,659,573 | 2,467 | 8-Nov | Oct-19 |
| 41 | Flushed Away | P/DW | $64,488,856 | 3,707 | $18,814,323 | 3,707 | 11-Mar | - |
| 42 | Deja Vu | BV | $64,038,616 | 3,108 | $20,574,802 | 3,108 | Nov-22 | 3-Jan |
| 43 | Miami Vice | Uni. | $63,450,470 | 3,026 | $25,723,815 | 3,021 | Jul-28 | 10-May |
| 44 | Tyler Perry's Madea's Family Reunion | LGF | $63,257,940 | 2,194 | $30,030,661 | 2,194 | Feb-24 | Apr-27 |
| 45 | The Holiday | Sony | $63,224,849 | 2,698 | $12,778,913 | 2,610 | 12-Aug | - |
| 46 | The Fast and the Furious: Tokyo Drift | Uni. | $62,514,415 | 3,030 | $23,973,840 | 3,027 | Jun-16 | 9-Jul |
| 47 | Underworld: Evolution | SGem | $62,318,875 | 3,207 | $26,857,181 | 3,207 | Jan-20 | 3-Dec |
| 48 | The Shaggy Dog | BV | $61,123,569 | 3,501 | $16,310,058 | 3,501 | 3-Oct | Jul-27 |
| 49 | Poseidon | WB | $60,674,817 | 3,555 | $22,155,410 | 3,555 | 5-Dec | 8-Oct |
| 50 | The Good Shepherd | Uni. | $59,908,565 | 2,250 | $9,912,110 | 2,215 | Dec-22 | 3-Aug |
| 51 | Little Miss Sunshine | FoxS | $59,891,098 | 1,602 | $370,998 | 7 | Jul-26 | Mar-29 |
| 52 | The Benchwarmers | SonR | $59,843,754 | 3,282 | $19,656,429 | 3,274 | 4-Jul | May-21 |
| 53 | Little Man | SonR | $58,645,052 | 2,537 | $21,613,176 | 2,533 | Jul-14 | Aug-27 |
| 54 | Curious George | Uni. | $58,360,760 | 2,609 | $14,703,405 | 2,566 | 2-Oct | 5-Apr |
| 55 | Invincible | BV | $57,806,952 | 2,987 | $17,031,122 | 2,917 | Aug-25 | Nov-16 |
| 56 | Blood Diamond | WB | $57,366,262 | 1,920 | $8,648,324 | 1,910 | 12-Aug | - |
| 57 | The Queen | Mira. | $56,222,759 | 1,850 | $122,014 | 3 | Sep-30 | - |
| 58 | The Guardian | BV | $55,011,732 | 3,241 | $18,006,064 | 3,241 | Sep-29 | 1-Apr |
| 59 | The Omen (2006) | Fox | $54,607,383 | 2,723 | $16,026,496 | 2,723 | 6-Jun | Aug-31 |
| 60 | Final Destination 3 | NL | $54,098,051 | 2,880 | $19,173,094 | 2,880 | 2-Oct | Apr-16 |
| 61 | The Prestige | BV | $53,089,891 | 2,305 | $14,801,808 | 2,281 | Oct-20 | - |
| 62 | The Lake House | WB | $52,330,111 | 2,645 | $13,616,196 | 2,645 | Jun-16 | Sep-21 |
| 63 | Apocalypto | BV | $50,866,635 | 2,465 | $15,005,604 | 2,465 | 12-Aug | 3-Aug |
| 64 | Firewall | WB | $48,751,189 | 2,840 | $13,635,463 | 2,840 | 2-Oct | May-18 |
| 65 | Date Movie | Fox | $48,548,426 | 2,898 | $19,076,261 | 2,896 | Feb-17 | 6-Jan |
| 66 | When a Stranger Calls | SGem | $47,860,214 | 3,004 | $21,607,203 | 2,999 | 2-Mar | Mar-19 |
| 67 | Hostel | Lions | $47,326,473 | 2,337 | $19,556,099 | 2,195 | 1-Jun | Feb-16 |
| 68 | Nanny McPhee | Uni. | $47,144,110 | 2,148 | $14,503,650 | 1,995 | Jan-27 | 5-Apr |
| 69 | Silent Hill | Sony | $46,982,632 | 2,932 | $20,152,598 | 2,926 | Apr-21 | Jun-18 |
| 70 | We Are Marshall | WB | $43,545,364 | 2,606 | $6,114,264 | 2,606 | Dec-22 | 3-Aug |
| 71 | Glory Road | BV | $42,647,449 | 2,397 | $13,594,734 | 2,222 | Jan-13 | 5-Nov |
| 72 | Lady in the Water | WB | $42,285,169 | 3,235 | $18,044,396 | 3,235 | Jul-21 | Sep-28 |
| 73 | The Hills Have Eyes | FoxS | $41,778,863 | 2,621 | $15,708,512 | 2,620 | 3-Oct | Jun-22 |
| 74 | John Tucker Must Die | Fox | $41,011,711 | 2,566 | $14,276,534 | 2,560 | Jul-28 | 11-Feb |
| 75 | Stranger Than Fiction | Sony | $40,435,190 | 2,270 | $13,411,093 | 2,264 | 11-Oct | Dec-21 |
| 76 | The Illusionist | YFG | $39,868,642 | 1,438 | $927,956 | 51 | Aug-18 | - |
| 77 | The Texas Chainsaw Massacre: The Beginning | NL | $39,517,763 | 2,820 | $18,508,228 | 2,820 | 10-Jun | 1-Apr |
| 78 | The Grudge 2 | Sony | $39,143,839 | 3,214 | $20,825,300 | 3,211 | Oct-13 | 11-Dec |
| 79 | Gridiron Gang | Sony | $38,432,823 | 3,510 | $14,414,630 | 3,504 | Sep-15 | Oct-22 |
| 80 | Last Holiday | Par. | $38,399,961 | 2,514 | $12,806,188 | 2,514 | Jan-13 | 3-Sep |
| 81 | The Nativity Story | NL | $37,629,831 | 3,183 | $7,849,304 | 3,183 | 12-Jan | Jan-18 |
| 82 | The Wild | BV | $37,384,046 | 2,854 | $9,684,809 | 2,854 | Apr-14 | Aug-17 |
| 83 | Man of the Year | Uni. | $37,327,390 | 2,626 | $12,299,380 | 2,515 | Oct-13 | Nov-30 |
| 84 | Pan's Labyrinth | PicH | $37,158,355 | 1,143 | $568,641 | 17 | Dec-29 | - |
| 85 | 16 Blocks | WB | $36,895,141 | 2,706 | $11,855,260 | 2,706 | 3-Mar | May-25 |
| 86 | Accepted | Uni. | $36,323,505 | 2,917 | $10,023,835 | 2,914 | Aug-18 | Oct-19 |
| 87 | The Sentinel | Fox | $36,280,697 | 2,851 | $14,367,854 | 2,819 | Apr-21 | Jul-27 |
| 88 | Children of Men | Uni. | $35,327,768 | 1,524 | $501,003 | 16 | Dec-25 | Mar-15 |
| 89 | Deck the Halls | Fox | $35,093,569 | 3,205 | $12,001,256 | 3,205 | Nov-22 | 2-Aug |
| 90 | Take the Lead | NL | $34,742,066 | 3,009 | $12,051,277 | 3,009 | 4-Jul | 6-Jan |
| 91 | Babel | ParV | $34,302,837 | 1,251 | $389,351 | 7 | Oct-27 | - |
| 92 | Snakes on a Plane | NL | $34,020,814 | 3,555 | $13,806,311 | 3,555 | Aug-18 | 11-Sep |
| 93 | She's the Man | P/DW | $33,741,133 | 2,631 | $10,730,372 | 2,623 | Mar-17 | 6-Jan |
| 94 | Flags of Our Fathers | P/DW | $33,602,376 | 2,375 | $10,245,190 | 1,876 | Oct-20 | Dec-14 |
| 95 | United 93 | Uni. | $31,483,450 | 1,871 | $11,478,360 | 1,795 | Apr-28 | 7-Jun |
| 96 | Employee of the Month | LGF | $28,444,855 | 2,579 | $11,407,751 | 2,579 | 10-Jun | Nov-30 |
| 97 | Garfield: A Tail of Two Kitties | Fox | $28,426,747 | 2,981 | $7,288,977 | 2,946 | Jun-16 | Sep-28 |
| 98 | The Ant Bully | WB | $28,142,535 | 3,050 | $8,432,465 | 3,050 | Jul-28 | Nov-16 |
| 99 | Crank | LGF | $27,838,408 | 2,515 | $10,457,367 | 2,515 | 9-Jan | Oct-19 |
| 100 | Stick It | BV | $26,910,736 | 2,044 | $10,803,610 | 2,038 | Apr-28 | Jul-27 |
| 101 | The Descent | LGF | $26,024,456 | 2,095 | $8,911,330 | 2,095 | 8-Apr | 10-Dec |
| 102 | Deep Sea 3-D (IMAX) | WB | $25,919,074 | 47 | $700,213 | 43 | 3-Mar | - |
| 103 | Thank You for Smoking | FoxS | $24,793,509 | 1,020 | $262,923 | 5 | Mar-17 | Sep-14 |
| 104 | Jet Li's Fearless | Rog. | $24,633,730 | 1,810 | $10,590,244 | 1,806 | Sep-22 | Nov-16 |
| 105 | Clerks II | MGM/W | $24,148,068 | 2,150 | $10,061,132 | 2,150 | Jul-21 | Sep-28 |
| 106 | An Inconvenient Truth | ParC | $24,146,161 | 587 | $281,330 | 4 | May-24 | 11-Feb |
| 107 | The Wicker Man | WB | $23,649,127 | 2,784 | $9,610,204 | 2,784 | 9-Jan | Nov-16 |
| 108 | The Covenant | SGem | $23,380,495 | 2,681 | $8,852,458 | 2,681 | 9-Aug | Oct-15 |
| 109 | Stay Alive | BV | $23,086,480 | 2,009 | $10,726,406 | 2,009 | Mar-24 | Jun-29 |
| 110 | The Black Dahlia | Uni. | $22,545,080 | 2,236 | $10,005,895 | 2,226 | Sep-15 | Oct-26 |
| 111 | My Super Ex-Girlfriend | Fox | $22,530,295 | 2,702 | $8,603,460 | 2,702 | Jul-21 | 10-Dec |
| 112 | Lucky Number Slevin | MGM/W | $22,495,466 | 1,989 | $7,031,921 | 1,984 | 4-Jul | Jul-20 |
| 113 | Waist Deep | Rog. | $21,344,312 | 1,006 | $9,404,180 | 1,004 | Jun-23 | 8-Mar |
| 114 | ATL | WB | $21,170,563 | 1,602 | $11,554,404 | 1,602 | Mar-31 | May-25 |
| 115 | Flicka | Fox | $21,000,147 | 2,877 | $7,703,551 | 2,877 | Oct-20 | 2-Aug |
| 116 | A Prairie Home Companion | PicH | $20,342,852 | 767 | $4,566,293 | 760 | 6-Sep | 10-Dec |
| 117 | Pulse | W/Dim. | $20,264,436 | 2,323 | $8,203,822 | 2,323 | 8-Nov | 10-Dec |
| 118 | Beerfest | WB | $19,185,184 | 2,964 | $7,031,228 | 2,964 | Aug-25 | 11-Feb |
| 119 | Akeelah and the Bee | LGF | $18,848,430 | 2,195 | $6,011,585 | 2,195 | Apr-28 | Jul-20 |
| 120 | The Marine | Fox | $18,844,784 | 2,545 | $7,138,774 | 2,545 | Oct-13 | Jan-25 |
| 121 | Aquamarine | Fox | $18,597,342 | 2,538 | $7,482,669 | 2,512 | 3-Mar | May-25 |
| 122 | Ultraviolet | SGem | $18,535,812 | 2,558 | $9,064,880 | 2,558 | 3-Mar | 4-Feb |
| 123 | School for Scoundrels | MGM/W | $17,807,569 | 3,007 | $8,602,333 | 3,004 | Sep-29 | - |
| 124 | The Last King of Scotland | FoxS | $17,449,410 | 540 | $142,899 | 4 | Sep-27 | - |
| 125 | Notes on a Scandal | FoxS | $17,436,676 | 682 | $414,487 | 22 | Dec-25 | - |
| 126 | Just My Luck | Fox | $17,326,650 | 2,543 | $5,692,285 | 2,541 | 5-Dec | 8-Mar |
| 127 | Annapolis | BV | $17,127,992 | 1,607 | $7,681,171 | 1,605 | Jan-27 | Apr-13 |
| 128 | Unaccompanied Minors | WB | $16,655,224 | 2,775 | $5,815,474 | 2,775 | 12-Aug | 3-Aug |
| 129 | An American Haunting | Free | $16,298,046 | 1,703 | $5,783,508 | 1,675 | 5-May | Jul-23 |
| 130 | Black Christmas | MGM/W | $16,235,738 | 1,544 | $3,723,364 | 1,544 | Dec-25 | Feb-15 |
| 131 | Marie Antoinette | Sony | $15,962,471 | 870 | $5,361,050 | 859 | Oct-20 | 12-Mar |
| 132 | Larry the Cable Guy: Health Inspector | LGF | $15,680,099 | 1,747 | $6,922,767 | 1,710 | Mar-24 | May-25 |
| 133 | Arthur and the Invisibles | MGM/W | $15,064,790 | 2,248 | N/A | 1 | Dec-29 | - |
| 134 | See No Evil | LGF | $15,032,800 | 1,270 | $4,581,233 | 1,257 | May-19 | 7-Jun |
| 135 | Tristan and Isolde | Fox | $14,734,633 | 1,845 | $6,583,135 | 1,845 | Jan-13 | Mar-30 |
| 136 | Everyone's Hero | Fox | $14,523,101 | 2,898 | $6,061,762 | 2,896 | Sep-15 | 12-Jul |
| 137 | Hollywoodland | Focus | $14,426,251 | 1,551 | $5,926,177 | 1,548 | 9-Aug | Oct-26 |
| 138 | Letters from Iwo Jima | WB | $13,704,488 | 781 | $89,097 | 5 | Dec-20 | - |
| 139 | One Night with the King | 8X | $13,395,961 | 909 | $4,120,497 | 909 | Oct-13 | 12-Jul |
| 140 | Friends with Money | SPC | $13,368,437 | 1,010 | $589,332 | 28 | 4-Jul | Aug-17 |
| 141 | Flyboys | MGM | $13,090,630 | 2,033 | $6,004,219 | 2,033 | Sep-22 | - |
| 142 | How to Eat Fried Worms | NL | $13,040,527 | 1,870 | $4,003,537 | 1,870 | Aug-25 | 10-Dec |
| 143 | Volver | SPC | $12,872,473 | 689 | $197,703 | 5 | 11-Mar | - |
| 144 | Bon Cop, Bad Cop | All. | $12,665,721 | 260 | $1,433,259 | 133 | 8-Apr | - |
| 145 | Idlewild | Uni. | $12,571,185 | 975 | $5,745,780 | 973 | Aug-25 | 10-May |
| 146 | Freedomland | SonR | $12,512,886 | 2,361 | $5,833,562 | 2,361 | Feb-17 | 3-Dec |
| 147 | The Protector | W/DD | $12,044,087 | 1,541 | $5,034,180 | 1,541 | 9-Aug | 11-Sep |
| 148 | Zoom | SonR | $11,989,328 | 2,501 | $4,510,408 | 2,501 | 8-Nov | Sep-17 |
| 149 | End of the Spear | RM | $11,967,000 | 1,163 | $4,281,388 | 1,163 | Jan-20 | 3-Sep |
| 150 | Dave Chappelle's Block Party | Rog. | $11,718,595 | 1,200 | $6,214,723 | 1,200 | 3-Mar | 4-Jun |